Figure 2.

Repeated andrographolide (Andro) administration induced significant antidepressant-like effects in the chronic unpredictable mild stress (CUMS) model of depression, as revealed by the forced swim test (FST) (B), tail suspension test (TST) (C), and sucrose preference test (SPT) (D). A schematic of the procedural timeline is shown in A. All results are represented as the means ± SEMs (n = 10); **P < .01 vs Vehicle; ^##P < .01 vs CUMS + Vehicle. The data were compared by 1-way ANOVA followed by the least significant difference (LSD) test.