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The usage of TrkB-shRNA fully abolished the antidepressant-like effects of andrographolide (Andro) both in naive mice (B) and in the chronic unpredictable mild stress (CUMS) model of depression (C–E). Schematics showing the timelines of the procedures are shown in (A). All results are represented as the means ± SEMs (n = 10); *P < .05, **P < .01 vs Vehicle; ##P < .01 vs CUMS + Vehicle. The data were compared by 1-way ANOVA followed by the least significant difference (LSD) test.
