#1	"Atrial Fibrillation"[Mesh] OR "atrial fibrillation"[tiab] OR (atrial[tiab] AND fibrillation[tiab]) OR afib[tiab] OR "atrial flutter"[MeSH Terms] OR "atrial flutter"[tiab]
#2	"warfarin"[MeSH Terms] OR warfarin[tw] OR coumadin[tw]
#3	"antithrombins"[MeSH Terms] OR "antithrombins"[tiab] OR ("direct"[tiab] AND "thrombin"[tiab] AND "inhibitors"[tiab]) OR "direct thrombin inhibitors"[tiab] OR "antithrombins"[Pharmacological Action]
#4	"Anticoagulants"[Mesh] OR "Anticoagulants" [Pharmacological Action] OR anticoagulant[tiab] OR anticoagulants[tiab]
#5	"evaluation studies"[Publication Type] OR "evaluation studies as topic"[MeSH Terms] OR "evaluation study"[tw] OR evaluation studies[tw] OR "intervention studies"[MeSH Terms] OR "intervention study"[tw] OR "intervention studies"[tw] OR "case-control studies"[MeSH Terms] OR "case-control"[tw] OR "cohort studies"[MeSH Terms] OR cohort[tw] OR "longitudinal studies"[MeSH Terms] OR "longitudinal"[tw] OR longitudinally[tw] OR "prospective"[tw] OR prospectively[tw] OR "retrospective studies"[MeSH Terms] OR "retrospective"[tw] OR "follow up"[tw] OR "comparative study"[Publication Type] OR "comparative study"[tw] OR systematic[subset] OR "meta-analysis"[Publication Type] OR "meta-analysis as topic"[MeSH Terms] OR "meta-analysis"[tw] OR "meta-analyses"[tw] OR randomized controlled trial[pt] OR controlled clinical trial[pt] OR randomized[tiab] OR randomised[tiab] OR randomization[tiab] OR randomisation[tiab] OR placebo[tiab] OR "drug therapy"[Subheading] OR randomly[tiab] OR trial[tiab] OR groups[tiab] OR Clinical trial[pt] OR "clinical trial"[tw] OR "clinical trials"[tw] NOT (Editorial[ptyp] OR Letter[ptyp] OR Case Reports[ptyp] OR Comment[ptyp])
#6	#1 AND #2 AND (#3 OR #4) AND #5
#7	#6 NOT (animals[mh] NOT humans[mh]), Limits: English, Publication Date from 2000 to present