#1	'atrial fibrillation'/exp OR 'heart atrium flutter'/exp OR 'atrial fibrillation':ab,ti OR 'atrial flutter':ab,ti
#2	'cerebrovascular disease'/de OR 'cerebrovascular accident'/exp OR 'thromboembolism'/exp OR 'bleeding'/de OR 'brain hemorrhage'/exp OR 'brain ischemia'/exp OR 'prothrombin time'/exp OR stroke:ab,ti OR strokes:ab,ti OR thromboembolism:ab,ti OR thromboembolisms:ab,ti OR thromboembolic:ab,ti OR thromboses:ab,ti OR hemorrhage:ab,ti OR hemorrhages:ab,ti OR hemorrhaging:ab,ti OR hemorrhagic:ab,ti OR haemorrhage:ab,ti OR haemorrhages:ab,ti OR haemorrhaging:ab,ti OR haemorrhagic:ab,ti OR ((bleeding OR bleed OR bleeds) NEAR/2 (major OR risk OR event)):ab,ti OR ((systemic OR paradoxical OR crossed) NEXT/2 (embolism OR embolisms)):ab,ti OR ((brain OR cerebral OR brainstem OR 'brain stem') NEXT/2 (ischemia OR ischaemia OR ischemias OR ischaemias OR infarction OR infarctions)):ab,ti OR (transient NEXT/2 (ischemic OR ischaemic OR ischaemia OR ischemia) NEXT/2 (attack OR attacks)):ab,ti OR tia:ab,ti OR tias:ab,ti OR 'cerebrovascular accident':ab,ti OR 'cerebrovascular accidents':ab,ti OR cva:ab,ti OR cvas:ab,ti OR 'brain vascular accident':ab,ti OR 'brain vascular accidents':ab,ti
#3	'risk'/exp OR risk:ab,ti OR risks:ab,ti OR 'safety'/exp OR safety:ab,ti OR safe:ab,ti OR 'incidence'/exp OR efficacy:ab,ti OR efficacious:ab,ti OR 'prevention':lnk OR prevent:ab,ti OR prevents:ab,ti OR preventing:ab,ti OR prevention:ab,ti OR 'treatment outcome'/exp OR 'adverse drug reaction':lnk OR (side NEXT/1 effect*):ab,ti OR (adverse NEXT/3 (interaction* OR response* OR effect* OR event* OR reaction* OR outcome*)):ab,ti OR (unintended NEXT/3 (interaction* OR response* OR effect* OR event* OR reaction* OR outcome*)):ab,ti OR (unintentional NEXT/3 (interaction* OR response* OR effect* OR event* OR reaction* OR outcome*)):ab,ti OR (unwanted NEXT/3 (interaction* OR response* OR effect* OR event* OR reaction* OR outcome*)):ab,ti OR (unexpected NEXT/3 (interaction* OR response* OR effect* OR event* OR reaction* OR outcome*)):ab,ti OR (undesirable NEXT/3 (interaction* OR response* OR effect* OR event* OR reaction* OR outcome*)):ab,ti OR 'drug safety':ab,ti OR 'drug toxicity':ab,ti OR tolerability:ab,ti OR harm:ab,ti OR harms:ab,ti OR harmful:ab,ti OR 'treatment emergent':ab,ti OR complication*:ab,ti OR toxicity:ab,ti
#4	#1 AND #2 AND #3
#5	'anticoagulant agent'/exp OR warfarin:ab,ti OR coumadin:ab,ti OR 'vitamin k':ab,ti OR enoxaparin:ab,ti OR lovenox:ab,ti OR rivaroxaban:ab,ti OR xarelto:ab,ti OR dabigatran:ab,ti OR pradaxa:ab,ti OR heparin:ab,ti OR apixaban:ab,ti OR eliquis:ab,ti OR edoxaban:ab,ti OR lixiana:ab,ti OR anticoagulant:ab,ti OR anticoagulants:ab,ti OR anticoagulation:ab,ti OR 'thrombin inhibitor':ab,ti OR 'thrombin inhibitors':ab,ti OR antithrombin:ab,ti OR antithrombins:ab,ti OR antithrombotic:ab,ti OR 'factor Xa inhibitor':ab,ti OR 'factor Xa inhibitors':ab,ti OR 'Blood clotting inhibitor':ab,ti OR 'blood clotting inhibitors':ab,ti OR clopidogrel:ab,ti OR plavix:ab,ti OR aspirin:ab,ti OR dipyridamole:ab,ti OR aggrenox:ab,ti OR persantine:ab,ti OR curantil:ab,ti OR antiplatelet:ab,ti OR anti-platelet:ab,ti OR antiplatelets:ab,ti OR anti-platelets:ab,ti OR 'platelet aggregation inhibitors':ab,ti OR 'platelet aggregation inhibitor':ab,ti OR 'platelet inhibitors':ab,ti OR 'platelet inhibitor':ab,ti OR 'platelet antagonists':ab,ti OR 'platelet antagonist':ab,ti
#6	('heart atrium appendage'/de AND 'surgery':lnk) OR 'septal occluder'/exp OR 'atrial appendage':ab,ti OR 'atrial appendages':ab,ti OR 'atrium appendage':ab,ti OR 'auricular appendage':ab,ti OR 'auricular appendages':ab,ti OR LAA:ab,ti OR occluder:ab,ti OR occluders:ab,ti OR occlusion:ab,ti OR AMPLATZER:ab,ti OR AtriClip:ab,ti OR PLAATO:ab,ti OR Watchman:ab,ti OR (atrial:ab,ti AND modification:ab,ti) OR lariat:ab,ti OR atricure:ab,ti
#7	#4 AND (#5 OR #6)
#8	#7 NOT ('case report'/exp OR 'case study'/exp OR 'editorial'/exp OR 'letter'/exp OR 'note'/exp OR [conference abstract]/lim)
#9	#8 AND [humans]/lim
#10	#9 NOT (('adolescent'/exp OR 'child'/exp) NOT 'adult'/exp)
#11	'clinical trial'/exp OR 'clinical study'/exp OR 'controlled study'/exp OR randomized:ab,ti OR randomised:ab,ti OR randomization:ab,ti OR randomisation:ab,ti OR randomly:ab,ti OR placebo:ab,ti OR trial:ab,ti OR groups:ab,ti OR 'crossover procedure'/exp OR 'double blind procedure'/exp OR 'single blind procedure'/exp OR crossover*:ab,ti OR (cross NEXT/1 over*):ab,ti OR 'clinical trial':ab,ti OR 'clinical trials':ab,ti OR 'clinical study':ab,ti OR 'clinical studies':ab,ti OR 'evaluation study'/exp OR 'evaluation study':ab,ti OR 'evaluation studies':ab,ti OR 'intervention study':ab,ti OR 'intervention studies':ab,ti OR 'case-control':ab,ti OR 'cohort analysis'/exp OR cohort:ab,ti OR longitudinal:ab,ti OR longitudinally:ab,ti OR 'prospective':ab,ti OR prospectively:ab,ti OR 'retrospective':ab,ti OR 'follow up'/exp OR 'follow up':ab,ti OR 'comparative study'/exp OR 'comparative study':ab,ti OR 'comparative studies':ab,ti OR 'systematic review':ab,ti OR 'meta-analysis':ab,ti OR 'meta-analyses':ab,ti OR 'meta synthesis':ab,ti OR 'meta syntheses':ab,ti OR 'survival analysis'/exp OR 'multicenter study'/exp OR 'multicenter study':ab,ti OR multicentre:ab,ti OR 'register'/exp OR registry:ab,ti OR registries:ab,ti OR 'sensitivity and specificity'/exp OR sensitivity:ab,ti OR specificity:ab,ti OR valid:ab,ti OR validity:ab,ti OR validation:ab,ti OR 'validation study'/exp
#12	#10 AND #11
#13	#12 AND [1-8-2011]/sd
#14	#13 AND [embase]/lim NOT [medline]/lim