#1	'heart atrium fibrillation'/exp OR 'heart atrium flutter'/exp OR “atrial fibrillation”:ab,ti OR (atrial:ab,ti AND fibrillation:ab,ti) OR afib:ab,ti OR “atrial flutter”:ab,ti
#2	'warfarin'/exp OR warfarin:ab,ti OR coumadin:ab,ti
#3	antithrombins:ab,ti OR (direct:ab,ti AND thrombin:ab,ti AND inhibitors:ab,ti) OR (direct:ab,ti AND thrombin:ab,ti AND inhibitor:ab,ti) OR "direct thrombin inhibitors":ab,ti OR “Antithrombin III":ab,ti OR “Antithrombin Proteins":ab,ti OR argatroban:ab,ti OR bivalirudin:ab,ti OR “Heparin Cofactor II":ab,ti OR Hirudins:ab,ti OR inogatran:ab,ti OR lepirudin:ab,ti OR melagatran:ab,ti OR “SDZ MTH 958":ab,ti OR ximelagatran:ab,ti
#4	'anticoagulant agent'/exp OR anticoagulant:ab,ti OR anticoagulants:ab,ti
#5	('randomized controlled trial'/exp OR 'crossover procedure'/exp OR 'double blind procedure'/exp OR 'single blind procedure'/exp OR random*:ab,ti OR factorial*:ab,ti OR crossover*:ab,ti OR (cross NEAR/1 over*):ab,ti OR placebo*:ab,ti OR (doubl* NEAR/1 blind*):ab,ti OR (singl* NEAR/1 blind*):ab,ti OR assign*:ab,ti OR allocat*:ab,ti OR volunteer*:ab,ti OR 'clinical study'/exp OR “clinical trial”:ti,ab OR “clinical trials”:ti,ab OR 'controlled study'/exp OR 'evaluation'/exp OR “evaluation study”:ab,ti OR “evaluation studies”:ab,ti OR “intervention study”:ab,ti OR “intervention studies”:ab,ti OR “case control”:ab,ti OR 'cohort analysis'/exp OR cohort:ab,ti OR longitudinal*:ab,ti OR prospective:ab,ti OR prospectively:ab,ti OR retrospective:ab,ti OR 'follow up'/exp OR “follow up”:ab,ti OR 'comparative effectiveness'/exp OR 'comparative study'/exp OR “comparative study”:ab,ti OR “comparative studies”:ab,ti OR 'evidence based medicine'/exp OR “systematic review”:ab,ti OR “meta-analysis”:ab,ti OR “meta-analyses”:ab,ti) NOT ('editorial'/exp OR 'letter'/exp OR 'case report'/exp)
#6	#1 AND #2 AND (#3 OR #4) AND #5
#7	#6 Limits: Humans, English, 2000 - present
#8	#7 AND [embase]/lim NOT [medline]/lim