Table 2A.

Strength of Evidence Domains For Prediction of Thromboembolic Risk

Outcome	Number of Studies (Subjects)	Risk of Bias	Consistency	Directness	Precision	SOE and Effect (95% CI)
CHADS2 (Categorical)	16 (548,464)	Observational/Moderate	Inconsistent	Direct	Precise	SOE=Moderate Limited risk prediction ability (c-statistics 0.66, 95% CI 0.63 to 0.69)
CHADS2 (Continuous)	14 (489,335)	Observational/Moderate	Inconsistent	Direct	Precise	SOE=Moderate Limited risk prediction ability (c-statistic=0.69; 95% CI 0.66 to 0.73)
CHA2DS2-VASc (Categorical)	13 (496,683)	Observational/Moderate	Inconsistent	Direct	Imprecise	SOE=Low Limited risk prediction ability (c-statistic=0.64; 95% CI 0.58 to 0.70)
CHA2DS2-VASc (Continuous)	16 (511,481)	Observational/Moderate	Inconsistent	Direct	Precise	SOE=Moderate Limited risk prediction ability (c-statistic=0.66; 95% CI 0.63 to 0.69)
Framingham (Categorical)	6 (282,572)	Observational/Moderate	Consistent	Direct	Precise	SOE=Moderate Limited risk prediction ability (c-statistic=0.63; 95% CI 0.62 to 0.65)
Framingham (Continuous)	4 (274,538)	Observational/Moderate	Consistent	Direct	Imprecise	SOE=Low Limited risk prediction ability (c-statistic ranges between 0.64 and 0.69 across studies)
ABC (Categorical)	4 (25,614)	Observational/Moderate	Consistent	Direct	Imprecise	SOE=Moderate Limited risk prediction ability (c-statistic=0.67; 95% CI 0.63 to 0.71)
Imaging Risk Tools	7 (4,962)	Observational/Moderate	Inconsistent	Direct	Imprecise	SOE=Insufficient

Abbreviations: CHADS₂=Congestive heart failure, Hypertension, Age ≥75, Diabetes mellitus, prior Stroke/transient ischemic attack (2 points); CHA₂DS₂-VASc=Congestive heart failure/left ventricular ejection fraction ≤ 40%, Hypertension, Age ≥75 (2 points), Diabetes mellitus, prior Stroke/transient ischemic attack/thromboembolism (2 points), Vascular disease, Age 65–74, Sex category female; CI=confidence interval; INR=international normalized ratio; NA=not applicable; SOE=strength of evidence