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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Thromb Haemost. 2018 Oct 30;118(12):2171–2187. doi: 10.1055/s-0038-1675400

Appendix Table 3.

C-statistics from Studies Comparing Stroke Risk Scores of Interest

Study CHADS2 Framingham CHA2DS2-VASc ABC-Stroke
Abraham, 201341 Continuous:
0.65 (95% CI 0.62 to 0.67)

Categorical:
0.65 (95% CI 0.62 to 0.67)		 Continuous:
0.67 (95% CI 0.65 to 0.69)

Categorical:
0.67 (95% CI 0.65 to 0.69)
Abumuaileq, 2015112 Continuous:
Non-anticoagulated cohort:
0.69 (95 % CI 0.53 to 0.85)

Anticoagulated cohort:
0.72 (95% CI 0.63 to 0.82)
Banerjee, 201372 Categorical:
0.64 (95% CI 0.61 to 0.67)		 Categorical:
0.64 (95% CI 0.62 to 0.67)
Banerjee, 2014113 Continuous:
0.641 (95% CI 0.607 to 0.676)		 Continuous:
0.621 (95% CI 0.616 to 0.683)
Baruch, 200734 Categorical (Classic):
0.64 (95% CI 0.61 to 0.67)

Categorical (Revised):
0.64 (95% CI 0.61 to 0.67)		 Categorical:
0.62 (95% CI 0.59 to 0.66)		 Categorical:
0.65 (95% CI 0.61 to 0.68)
Fang, 200833 Continuous:
All patients: 0.60

Categorical:
All patients: 0.58
Off therapy: 0.67		 Continuous:
All patients: 0.64

Categorical:
All patients: 0.62
Off therapy: 0.69
Friberg, 201218 Continuous:
0.66 (95% CI 0.65 to 0.66)

Categorical (Revised):
0.61 (95% CI 0.61 to 0.62)

Categorical (Classic):
0.64 (95% CI 0.64 to 0.65)		 Continuous:
0.67 (95% CI 0.66 to 0.67)

Categorical:
0.64 (95% CI 0.64 to 0.65)		 Continuous:
0.67 (95% CI 0.67 to 0.68)

Categorical:
0.56 (95% CI 0.56 to 0.57)
Friberg, 201571 Continuous:
0.72 (95% CI 0.72 to 0.73)		 Continuous:
0.71 (95% CI 0.71 to 0.72)
Gage, 200135 Continuous:
0.82 (95% CI 0.80 to 0.84)
Hijazi, 201656 Continuous:

Derivation cohort: 0.62 (95% CI 0.60 to 0.65)

Validation cohort: 0.58 (95% CI 0.49 to 0.67)		 Categorical:

Derivation cohort, TnI: 0.68 (95% CI 0.65 to 0.71)

Derivation cohort, TnT: 0.67 (95% CI 0.65 to 0.70)

Validation cohort, TnT: 0.66 (95% CI 0.58 to 0.74)
Primary paper:
Granger, 201157

Relevant companion:
Hijazi, 2017114 		Categorical:

Baseline data:
TnI: 0.71 (95% CI 0.66 to 0.76)

TnT: 0.70 (95% CI 0.65 to 0.75)

2 months:
TnI: 0.72 (95% CI 0.66 to 0.77)

TnT: 0.70 (95% CI 0.65 to 0.76)
Primary paper: O’Brien, 201590

Relevant companion: Inohara, 201795 		Continuous:
0.679 (95% CI 0.651 to 0.707)
Larsen, 201244 Continuous:
0.68 (95% CI 0.59 to 0.76)		 Continuous:
0.69 (95% CI 0.60 to 0.77)
Lip, 201037 Continuous:
0.60 (95% CI 0.49 to 0.72)

Categorical (Classic):
0.56 (95% CI 0.44 to 0.66)

Categorical (Revised):
0.59 (95% CI 0.48 to 0.70)		 Continuous:
0.69 (95% CI 0.60 to 0.78)

Categorical:
0.64 (95% CI 0.53 to 0.74)
McAlister, 2017115 Categorical:
0.663 (95% CI 0.652 to 0.675)		 Categorical:
0.661 (95% CI 0.649 to 0.672)
Oldgren, 201658 Continuous:
0.60 (95% CI 0.57 to 0.64)		 Categorical:
0.65 (95% CI 0.61to 0.69)
Olesen, 201123 Covariates analyzed as categorical variables:
Continuous:
0.78 (95% CI 0.76 to 0.80)

Categorical:
0.81 (95% CI 0.80 to 0.83)

Covariates analyzed as continuous variables:
Continuous:
0.80 (95% CI 0.79 to 0.82)

Categorical:
0.81 (95% CI 0.80 to 0.83)		 Covariates analyzed as categorical variables:
Continuous:
0.78 (95% CI 0.76 to 0.79)

Categorical:
0.89 (95% CI 0.88 to 0.90)

Covariates analyzed as continuous variables:
Continuous:
0.79 (95% CI 0.78 to 0.81)

Categorical:
0.89 (95% CI 0.88 to 0.90)
Olesen, 201239 Categorical:
0.63 (95% CI 0.62 to 0.65)		 Continuous:
0.66 (95% CI 0.65 to 0.68)
Philippart 2016116 Categorical:
0.588 (95% CI 0.577-0.599)

Continuous:
0.641 (95% CI 0.631-0.652)
Poli, 200930 Categorical:
All patients: 0.68
On therapy: 0.52
Poli, 201126 Continuous (Revised):
0.72 (95% CI 0.64 to 0.80)

Categorical (Classic):
0.68 (95% CI 0.61 to 0.76)

Categorical (Revised):
0.60 (95% CI 0.51 to 0.67)		 Continuous:
0.72 (95% CI 0.65 to 0.80)

Categorical:
0.52 (95% CI 0.44 to 0.61)
Potpara, 201220 Categorical:
0.58 (95% CI 0.38 to 0.79)		 Categorical:
0.72 (95% CI 0.61 to 0.84)
Rietbrock, 200832 Continuous (Classic):
0.68 (95% CI 0.68 to 0.69)

Continuous (Revised):
0.72 (95% CI 0.72 to 0.73)
Primary paper: Rivera-Caravaca, 201754

Relevant companion:
Rivera-Caravaca, 2017102 		Categorical (3.5 years):
0.600 (95% CI 0.567 to 0.625)

Categorical (6.5 years):
0.620 (95% CI 0.590 to 0.648)		 Categorical (3.5 years):
0.663 (95% CI 0.634 to 0.690)

Categorical (6.5 years):
0.662 (95% CI 0.633 to 0.690)
Ruff, 201648 Continuous:
0.586 (95% CI 0.565 to 0.607)
Ruiz Ortiz, 201027 Continuous:
0.63 (95% CI 0.55 to 0.72)
Singer, 201342 Continuous:
0.69 (95% CI 0.67 to 0.71)

Categorical:
0.66 (95% CI 0.64 to 0.68)		 Continuous:
0.70 (95% CI 0.68 to 0.72)

Categorical:
0.58 (95% CI 0.57 to 0.59)
van den Ham, 201545 Continuous:
0.68 (95% CI 0.67 to 0.69)

Categorical (published low/moderate/high)
0.65 (95% CI 0.64 to 0.66)

Categorical (optimized)
0.65 (95% CI 0.64 to 0.66)		 Continuous:
0.68 (95% CI 0.67 to 0.69)

Categorical (published low/moderate/high)
0.59 (95% CI 0.59 to 0.60)

Categorical (optimized)
0.63 (95% CI 0.62 to 0.64)
Van Staa, 201124 Continuous:
0.66 (95% CI 0.64 to 0.68)

Categorical:
0.65 (95% CI 0.63 to 0.67)		 Continuous:
0.65 (95% CI 0.63 to 0.68)

Categorical:
0.62 (95% CI 0.60 to 0.64)		 Continuous:
0.67 (95% CI 0.65 to 0.69)

Categorical:
0.60 (95% CI 0.59 to 0.61)
Wang, 200355 Categorical:
0.62		 Categorical:
0.66 (SD 0.03)

Abbreviations: CHADS2=Congestive heart failure, Hypertension, Age ≥75, Diabetes mellitus, prior Stroke/transient ischemic attack (2 points); CHA2DS2-VASc=Congestive heart failure/left ventricular ejection fraction ≤ 40%, Hypertension, Age ≥75 (2 points), Diabetes mellitus, prior Stroke/transient ischemic attack/thromboembolism (2 points), Vascular disease, Age 65–74, Sex category female; CI=confidence interval; SD=standard deviation