Table 2.
IBD N=49 |
No IBD N=96 |
P | |
---|---|---|---|
Conditioning Regimen Intensity | |||
Myeloablative | 9 (18.4%) | 28 (29.2%) | 0.158 |
Reduced Toxicity/Reduced Intensity | 40 (81.6%) | 68 (70.8%) | |
Conditioning Regimen Serotherapy | |||
Anti-Thymocyte Globulin | 19 (38.8%) | 40∧ (42.6%) |
0.908 |
Alemtuzumab | 26 (53.1%) | 47∧ (50.0%) |
|
None | 4 (8.2%) | 7A (7.4%) | |
Donor and Recipient Relation and HLA Match | 0.689 | ||
Matched Sibling Donor | 8 (16.3%) | 22 (22.9%) | |
Matched Other Related Donor | 4 (8.2%) | 4 (4.2%) | |
Mismatched Related Donor& | 2 (4.1%) | 5 (5.2%) | |
Matched Unrelated Donor | 29 (59.2%) | 50 (52.1%) | |
Mismatched Unrelated Donor% | 6 (12.2%) | 15 (15.6%) | |
Graft Source | <0.001 | ||
Bone Marrow | 20 (40.8%) | 61 (63.5%) | |
Peripheral Blood Stem Cell | 23 (46.9%) | 15 (15.6%) | |
Cord Blood | 6 (12.2%) | 17 (17.7%) | |
Bone Marrow and Cord Blood | 0 | 3 (3.1%) | |
Graft Manipulation to Achieve T-cell Depletion | 0 | 2* (2.1%) | 0.454 |
Acute GVHD Prophylaxis | 0.003 | ||
Calcineurin Inhibitor +/− 1 or More Additional Agents | 29 (59.2%) | 79 (82.3%) | |
Other | 20 (40.8%) | 15 (15.6%) | |
None | 0 | 2 (2.1%) | |
Serotherapy was reported for 94 patients without IBD
Three patients received a 7/8 HLA matched graft, 1 patient received a 6/8 HLA matched graft, 1 patient received a 5/8 HLA matched graft, and 2 patients received haploidentical grafts
Two patients received a 4/6 HLA matched graft, 3 patients received a 5/8 HLA matched graft, 5 patients received a 6/8 HLA matched graft, 11 patients received a 7/8 HLA matched graft
Graft manipulation was reported for 95 patients without IBD