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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: J Clin Immunol. 2019 Aug 2;39(7):653–667. doi: 10.1007/s10875-019-00659-8

Table 2.

Transplant procedures in patients with and without IBD.

IBD
N=49
No IBD
N=96
P
Conditioning Regimen Intensity
 Myeloablative 9 (18.4%) 28 (29.2%) 0.158
 Reduced Toxicity/Reduced Intensity 40 (81.6%) 68 (70.8%)
Conditioning Regimen Serotherapy
 Anti-Thymocyte Globulin 19 (38.8%) 40
(42.6%)
0.908
 Alemtuzumab 26 (53.1%) 47
(50.0%)
 None 4 (8.2%) 7A (7.4%)
Donor and Recipient Relation and HLA Match 0.689
 Matched Sibling Donor 8 (16.3%) 22 (22.9%)
 Matched Other Related Donor 4 (8.2%) 4 (4.2%)
 Mismatched Related Donor& 2 (4.1%) 5 (5.2%)
 Matched Unrelated Donor 29 (59.2%) 50 (52.1%)
 Mismatched Unrelated Donor% 6 (12.2%) 15 (15.6%)
Graft Source <0.001
 Bone Marrow 20 (40.8%) 61 (63.5%)
 Peripheral Blood Stem Cell 23 (46.9%) 15 (15.6%)
 Cord Blood 6 (12.2%) 17 (17.7%)
 Bone Marrow and Cord Blood 0 3 (3.1%)
Graft Manipulation to Achieve T-cell Depletion 0 2* (2.1%) 0.454
Acute GVHD Prophylaxis 0.003
 Calcineurin Inhibitor +/− 1 or More Additional Agents 29 (59.2%) 79 (82.3%)
 Other 20 (40.8%) 15 (15.6%)
 None 0 2 (2.1%)

Serotherapy was reported for 94 patients without IBD

&

Three patients received a 7/8 HLA matched graft, 1 patient received a 6/8 HLA matched graft, 1 patient received a 5/8 HLA matched graft, and 2 patients received haploidentical grafts

%

Two patients received a 4/6 HLA matched graft, 3 patients received a 5/8 HLA matched graft, 5 patients received a 6/8 HLA matched graft, 11 patients received a 7/8 HLA matched graft

*

Graft manipulation was reported for 95 patients without IBD