Table 4.

Multivariate analysis of risk of acute GVHD grades II-IV including patients with or without IBD (A, N=132 evaluable patients) or including patients stratified by control or not of IBD (B, N=131 evaluable patients).

4A Baseline IBD
Parameter	N (N Event)	HR (%95 CI)	P-value
Baseline IBD status
No (reference)	85 (17)	1.00
Yes	47 (16)	1.98 (1.00, 3.94)	0.051
Donor type (combined)
Matched donor (MUD, MORD or MSD) (reference)	108 (20)	1.00
Mismatched donor (MMUD or MMRD)	24 (13)	4.03 (1.99, 8.17)	0.0001

4B IBD Status (Controlled or Not)
Parameter	N (N Event)	HR (%95 CI)	P-value
IBD status at Treatment
No (reference)	85 (17)	1.00
IBD Controlled	31* (10)	1.89 (0.86, 4.15)	0.112
IBD Uncontrolled	15* (5)	1.86 (0.69, 5.05)	0.223
Donor type (combined)
Matched donor (MUD, MORD or MSD) (reference)	107(19)	1.00
Mismatched donor (MMUD or MMRD)	24 (13)	4.16 (2.04, 8.51)	<0.0001

^*One patient with IBD was reported to have unknown control at the time of HCT and was excluded

MUD, Matched Unrelated Donor

MORD, Matched Other Related Donor

MSD, Matched Sibling Donor

MMUD, Mismatched Unrelated Donor

MMRD, Mismatched Related Donor

“N” is the number of subjects in the category of the variable; the “N event” is defined by acute GVHD grades II-IV.

The “HR” is for the estimate of acute GVHD grades II-IV.

For each “parameter”, the alternative category is compared with the reference group.

“P-value” provides the overall significance of the variable in the model.