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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Brain Behav Immun. 2019 Jun 27;81:388–398. doi: 10.1016/j.bbi.2019.06.035

Figure 1. Simultaneous deletion of CREB and expression of GFP-L10a.

Figure 1.

A, schematic of bilateral hippocampal injections of AAV2/9-Cre expressing virus into the dorsal and ventral hippocampus. Image made from the Allen Institute for Brain Science Atlas (Allen Brain Institue, 2015). B, 6 weeks after injection of AAV-Cre, there is robust expression of GFP-L10a specifically in the hippocampus. C, western blotting of hippocampal lysate 6 weeks after injection of AAV-Cre. CREB1 was normalized to GAPDH, N =4, Student’s t-test P =0.018. D, RNA-sequencing read alignment to the C57BL6 reference genome showed a reduction in transcripts at the floxed region of the AAV-Cre injected mice.