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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Brain Behav Immun. 2019 Jun 27;81:388–398. doi: 10.1016/j.bbi.2019.06.035

Figure 4. The physiological effects of UCMS are decreased with hippocampal CREB deletion.

Figure 4.

A, experimental timeline for viral injections, UCMS protocol, behavioral assays, and physiological evaluations. B, sucrose consumption during a 1-hour SCT. Reported as amount of sucrose drunk in grams. Two-way ANOVA, F1,35=6.445, P=0.016. C, percent weight change from baseline during the UCMS paradigm was measured on days 7, 21, and 35. Two-way repeated measures ANOVA, F9,105 = 4.99 P<0.0001 (a= P < 0.05 for stress-Cre compared to all other groups, b = P < 0.05 for stress-GFP compared to all other groups, and c = P < 0.0001 for stress-GFP compared to all other groups). D, the core body temperature was decreased in the stress-GFP group compared to the no stress-GFP control group (P = 0.005) and the stress-Cre groups (P = 0.01), but there was no difference between the stress- Cre and no stress-Cre groups. Two-way ANOVA, F1, 35 = 6.546, P = 0.0150.