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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Brain Behav Immun. 2019 Jun 27;81:388–398. doi: 10.1016/j.bbi.2019.06.035

Figure 6. Hippocampal CREB deficiency changes affective behavior.

Figure 6.

A, CREB-deficient mice had a baseline increase in the latency to eat palatable food in the NSF test (F1, 32 = 9.803, P =0.0037, stress-GFP N =13; stress-Cre N =12; no stress-GFP N =6; and no stress-Cre N =5). The non-significant trend toward an increase in latency due to stress in the GFP group was not observed in the Cre group. C, CREB deficiency or stress did not change time spent in the open area in the elevated zero maze test, D, or in the overall locomotor activity of mice during 60 minutes of monitoring.