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. Author manuscript; available in PMC: 2020 Sep 28.
Published in final edited form as: J Control Release. 2019 Aug 17;310:94–102. doi: 10.1016/j.jconrel.2019.08.019

Figure 5.

Figure 5.

Resolving in vivo tissue retention into solid dihydrate and dissolved paclitaxel for rabbit aorta. (A) In vivo dissolution of the dihydrate paclitaxel coating follows beyond 28d and up to 62d post treatment. (B) Simulated extracellular (Cex) and intracellular (Cin) concentrations of soluble paclitaxel at the coating-tissue interface normalized to theoretical Cmax = 4.3 nM (Eq. 7). (C) Simulated bulk tissue concentrations of dissolved paclitaxel, receptor bound (red dashed) and total concentrating of free and bound drug (black line).