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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Environ Int. 2019 Aug 8;132:105012. doi: 10.1016/j.envint.2019.105012

Table 3.

Associations between plasma fluoride and kidney and liver measures

Outcomes Unstandardized Beta
(95% Cl)		 Uncorrected p Holm-Bonferroni
Corrected p
eGFR −10.36 (−17.50, −3.22) 0.01 0.05*
SUA 0.29 (0.09, 0.50) 0.01 0.05*
ACRa 0.08 (−0.04, 0.19) 0.20 >0.99
BUN −1.29 (−1.87, −0.70) <0.001 <0.001*
ALT a 0.03 (−0.02, 0.08) 0.27 >0.99
ALPa, b 0.00 (−0.01, 0.01) 0.95 >0.99
AST a 0.00 (−0.04, 0.04) >0.99 >0.99
Serum albumin −0.03 (−0.09, 0.03) 0.29 >0.99
GGT −0.71 (−1.92, 0.50) 0.24 >0.99

Note. Regression analyses were adjusted for age, sex, race, body mass index, ratio of family income to poverty and daily protein intake. Sampling weights were applied to these regression analyses; N=25,930,302; unweighted n = 1983; MEC weights were re-weighted to our dietary sample for regression analyses;

a

Plasma fluoride exposure and outcome variables were log2 transformed;

b

Model included a quadratic term;

*

Significant at p ≤ 0.05 after Holm-Bonferroni correction; Regression results remained consistent regardless of whether MEC weights or re-weighted MEC weights were applied.