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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Brain Behav Immun. 2019 Jun 24;81:374–387. doi: 10.1016/j.bbi.2019.06.034

Fig. 5. “Two-hit” and LPS-injected mice display Impaired spatial learning in Morris water maze at 7.5 months after injection.

Fig. 5.

Mice were 42 weeks in age at time of testing, following treatment with DSP-4 and/or LPS at 9-10 weeks. (A-B) Acquisition of spatial learning in the Morris water maze. Data are means (± SEM) of 4 trials per day, across 5 days of training. (A) Latency to find the escape platform in the Morris water maze. (B) Swimming distance. (C-D) The decrease in spending percent time, [within-group analyses following repeated measures ANOVA, treatment x quadrant interaction, F(9,60)=2.06, p=0.0473; and quadrant, F(3,60)=13.51, p<0.0001] (C) and crossing times, [effect of quadrant, F(3,60)=7.80, p=0.0002; ] (D) in target quadrant in LPS alone and “two-hit” mice. Data are means (± SEM) for a one-minute probe trial, with the escape platform removed from the water maze. The target quadrant indicates the location of the platform during training. N=6 mice per treatment group. *p<0.05, significant effect of quadrant, within-treatment repeated measures ANOVA.