Male C57BL/6J mice were tested at 11 or 18.5 months after injection with DSP-4/LPS. In the older mice, combined treatment with DSP-4 and LPS led to significantly longer latencies to locate the buried food, [F(1,30)=7.72, p=0.0093], N=5-7 mice per treatment group at 11 months, and 5-12 mice per treatment group at 18.5 months after injections. *p<0.05, comparison to Vehicle.