Table 3.
Correlation between serum fibroblast growth factor 21 levels and clinical variables among the 126 patients with type 2 diabetes mellitus.
| Variables | Logarithmically transformed fibroblast growth factor 21 (pg/mL) | ||||
|---|---|---|---|---|---|
| Univariate | Multivariate | ||||
| R | P value | Beta | Adjusted R2change | P value | |
| Women | 0.172 | 0.055 | — | — | — |
| Hypertension | 0.201 | 0.024∗ | — | — | — |
| Age (years) | 0.121 | 0.179 | — | — | — |
| Height (cm) | –0.059 | 0.513 | — | — | — |
| Body weight (kg) | 0.168 | 0.060 | — | — | — |
| Body mass index (kg/m2) | 0.259 | 0.003∗ | — | — | — |
| Waist circumference (cm) | 0.301 | 0.001∗ | — | — | — |
| Body fat mass (%) | 0.359 | <0.001∗ | 0.218 | 0.218 | 0.008∗ |
| SBP (mmHg) | 0.191 | 0.032∗ | — | — | — |
| DBP (mmHg) | 0.180 | 0.043∗ | — | — | — |
| Total cholesterol (mg/dL) | 0.163 | 0.068 | — | — | — |
| Log-triglyceride (mg/dL) | 0.499 | <0.001∗ | 0.357 | 0.036 | <0.001∗ |
| HDL-C (mg/dL) | –0.219 | 0.014∗ | — | — | — |
| LDL-C (mg/dL) | 0.176 | 0.049∗ | — | — | — |
| Log-glucose (mg/dL) | 0.187 | 0.036∗ | — | — | — |
| Log-HbA1c (%) | 0.059 | 0.517 | — | — | — |
| Log-BUN (mg/dL) | 0.001 | 0.996 | — | — | — |
| Log-creatinine (mg/dL) | 0.194 | 0.029∗ | — | — | — |
| eGFR (mL/min) | –0.325 | <0.001∗ | –0.205 | 0.033 | 0.013∗ |
| Log-UACR (mg/g) | 0.198 | 0.031∗ | — | — | — |
| Log-insulin (μIU/mL) | 0.334 | <0.001∗ | — | — | — |
| Log-HOMA-IR | 0.358 | <0.001∗ | — | — | — |
Data of triglyceride, glucose, HbA1c, BUN, creatinine, UACR, insulin, and HOMA-IR levels showed skewed distribution and therefore were log-transformed before analysis. Analysis of data was done using the univariate linear regression analysis or multivariate stepwise linear regression analysis (adapted factors were hypertension, body mass index, waist circumference, body fat mass, SBP, DBP, log-triglyceride, HDL-C, LDL-C, log-glucose, log-creatinine, eGFR, log-UACR, insulin, and HOMA-IR). SBP, systolic blood pressure; DBP, diastolic blood pressure; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; HbA1c, glycated hemoglobin; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; UACR, urine albumin-to-creatinine ratio; HOMA-IR, homeostasis model assessment of insulin resistance. ∗P < 0.05 was considered statistically significant.