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. 2019 Sep 8;2019:2165918. doi: 10.1155/2019/2165918

Figure 3.

Figure 3

Inhibition of synovial macrophage pyroptosis may alleviate fibrosis in KOA rats. (a) The severity of synovial fibrosis evaluated by the transverse diameters of the right knees. ∗P < 0.05 vs. the Normal group; #P < 0.05 vs. the KOA+AYC group. (b) Collagen deposition was revealed through Sirius Red staining (200×). (c) Semiquantification of Sirius Red staining was evaluated using the average integral optical density (AIOD). The results were expressed as the mean ± SD (n = 6). ∗P < 0.05, in comparison with the Normal group. #P < 0.05, in comparison with the KOA group. Data were analyzed by ImageJ. (d) Comparison of TGF-β, PLOD2, COL1A1, and TIMP1 protein expressions between groups. ∗P < 0.05, in comparison with the Normal group. #P < 0.05, in comparison with the KOA group (n = 6). (e) Typical protein bands for each group. (f) The mRNA levels of TGF-β, PLOD2, COL1A1, and TIMP1 between groups.