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Pyroptosis is induced in LPS+ATP-treated macrophages. (a) The silencing effects of the caspase1 siRNA and GSDMD siRNA were both confirmed by PCR. (b) Pyroptotic cells observed by Hoechst and PI staining (200×). (c) Comparison of NLRP3, ASC, GSDMD, and GSDMD-N protein expressions between groups. ∗P < 0.05, in comparison with the Normal group. #P < 0.05, in comparison with the KOA group. (d) Typical protein bands for each group.
