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. 2019 Sep 8;2019:2782417. doi: 10.1155/2019/2782417

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Copyright © 2019 Fei Xing et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of premicroinjection and postmicroinjection of TRPV1 siRNA in CCI-induced neuropathic pain. (a, b) Premicroinjection of TRPV1 in the ipsilateral DRG prevented CCI-induced decreases in PWT (a) and PWL (b). ^∗P < 0.05 and ^∗∗P < 0.01 vs. the vehicle+CCI group (two-way ANOVA). (c, d) Postmicroinjection of TRPV1 in the ipsilateral DRG abolished the established CCI-induced nociceptive changes in PWT (c) and PWL (d). ^∗∗P < 0.01 vs. the CCI+vehicle group (two-way ANOVA). No change was observed in PWT and PWL of rats premicroinjected or postmicroinjected with MZF1 scrRNA (a–d).