Figure 4. Glucose- and capsaicin-induced insulin secretion by pancreatic minces. Samples incubated in KRB medium containing 2 mmol/l glucose (2G) or 8 mmol/l glucose (8G) (A), or capsaicin (cap) (B). (C) AMG9810 (AMG, a selective TRPV1 antagonist), CGRP8-37 (a selective CGRP receptor antagonist), or RP67580 (RP, a selective NK1 receptor antagonist) was added 5 min before adding glucose (8 mmol/l). Values are mean±SEM; n=4; *p<0.05 vs. WT-2G; †p<0.05 vs. WT-8G (or TRPV1–/– 2G); ‡p<0.05 vs. WT-8G (or WT-cap).