Table 4.

Succinylation alters select metabolic pathways and enzymes.

Pathway	Affected enzymes and products	Model	Reference
TCA cycle	PDHC, SDH	SIRT5 KO mouse liver and SIRT5 KO MEFs	[34]
	ATP level	SIRT5 KO mouse heart	[13]
	IDH	E. coli	[2]
	IDH	Pure protein	[62]
Redox state	SOD1	293T cells	[42]
Respiratory Chain	F1F0 ATP synthase, respiratory chain complexes (complexes I, III, and IV)	SIRT5 KO mouse liver and SIRT5 KO MEFs	[34]
	membrane proteins (Complex I and II), ATP synthase	SIRT5 KO mouse	[43]
	Complex II (SDH)	HT1080 cells stably overexpressing SIRT5	[23]
Val-Leu-Ile degradation pathway	-	SIRT5 KO mouse liver and SIRT5 KO MEFs	[34]
Fatty acid metabolism	-	SIRT5 KO mouse liver and SIRT5 KO MEFs	[34]
	ECHA	SIRT5 KO mouse heart	[13]
Ketogenesis	HMGCS2, HMG CoA	SIRT5 KO mouse liver mitochondria	[44]
	Mitochondrial acetyl CoA acetyltransferase	SIRT5 KO MEFs	[34]
UREA cycle	CPS1	SIRT5 KO mouse	[6]