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Helical domain in Class 2 OLD proteins shares structural homology with R–M system controller proteins. (A) Structural superposition of Bp OLD helical domain (yellow) with Esp1396I.C controller protein (raspberry; PDB: 3CLC). (B) Topology diagrams of Bp OLD helical domain and Esp1361.C monomer. (C) Bp OLD architecture precludes dimerization as in controller proteins and suggests an alternate mode of DNA binding.
