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. 2019 Sep 23;10(10):705. doi: 10.1038/s41419-019-1942-1

Fig. 3. Analysis of bone mass and biomechanical property of skeletal tissue.

Fig. 3

miR-29a overexpression reduced the ovariectomy-induced excessive body weight gain (a) and retained abundant trabecular microstructure (b); scale bar: 5 mm. The ovariectomy-induced loss of BMD (c), bone area (d), B.Ar/T.Ar (e), Tb.Th (f), Tb.N (g), and connectivity (h) were attenuated in miR-29aTg/OCN mice, whereas Tb.Sp (i) and SMI (j) were improved. Load-displacement curve (k) showed minor responses to ovariectomy-induced downregulation of maximum force (l) and breaking force (m) in miR-29aTg/OCN mice. The data are expressed mean ± SEM calculated from six mice. Asterisks * and hashtags # indicate significant difference from sham controls and OVX, respectively. Ampersands & indicate significant difference from Tg-Sham and Tg-OVX