Fig. 5. miR-29a precursor treatment for bone microstructure and histology.

miR-29a precursor attenuated the ovariectomy-induced loss of trabecular microarchitecture (a); scale bar: 5 mm; BMD, BV/TV, and Tb.Th (b), as well as improved load-displacement profile (c), maximum force and breaking force (d). The treatment retained fluorescent calcein accumulation (scale bar: 40 μm) and MAR (e) and compromised the ovariectomy upregulation of osteoclast distribution (scale bar: 8 μm) and Oc.N (f). The data are expressed mean ± SEM calculated from eight mice. Asterisks * and hashtags # indicate significant difference from sham controls and OVX, respectively