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. 2019 Aug 22;20(4):3499–3508. doi: 10.3892/mmr.2019.10602

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Copyright: © Dai et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — MALAT1-knockdown-induced malignancy changes are recovered by inhibition of miR-1-3p. A wound healing assay was performed to measure the migratory ability of (A) LNCaP and (B) 22RV1 cells following inhibition of MALAT1 and miR-1-3p (Scale bar, 200 µm). (C) The migration rate in LNCaP and 22RV1 cells was quantified. (D) A Transwell assay with Matrigel and (E) quantitative analysis to detect the invasive ability of prostate cancer cells following silencing of MALAT1 and miR-1-3p (Scale bar, 100 µm). (F) Western blotting of the expression levels of EMT-associated proteins, E-cadherin, N-cadherin, vimentin, Slug and Snail in (G) LNCaP and (H) 22RV1. **P<0.01 and ***P<0.001. MALAT1, metastasis-associated lung adenocarcinoma transcript 1; EMT, epithelial-mesenchymal transition; N, neural; e, epithelial; sh, short hairpin; NC, negative control; miR, microRNA.