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. 2019 Aug 22;20(4):3499–3508. doi: 10.3892/mmr.2019.10602

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Copyright: © Dai et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Phenotypic alterations induced by silencing of MALAT1 is abolished by forced expression of CORO1C. (A) Western blotting and (B) quantitative analysis of the CORO1C expression levels were detected following CORO1C overexpression. Wound healing assay was performed to measure the migratory rate in (C) LNCaP and (D) 22RV1 cells following MALAT1 knockdown or/and CORO1C overexpression (Scale bar, 200 µm) and (E) quantitative analysis. (F) Transwell assay and (G) quantitative analysis to investigate the invasive ability of LNCaP and 22RV1 cells (Scale bar, 100 µm). (H) Western blotting of the expression levels of EMT-associated proteins, E-cadherin, N-cadherin, vimentin, Slug and Snail in (I) LNCaP and (J) 22RV1. ***P<0.001. MALAT1, metastasis-associated lung adenocarcinoma transcript 1; EMT, epithelial-mesenchymal transition; CORO1C, coronin 1C; N, neural; e, epithelial; sh, short hairpin; NC, negative control; miR, microRNA.