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. 2019 Aug 29;20(4):3679–3690. doi: 10.3892/mmr.2019.10627

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Selection of optimal prognostic genes. (A) Curve of cvl screening for the λ parameter. The optimized parameter λ, indicator of the hazard, was obtained by 1,000 rounds of cross-validated likelihood (cvl) circular calculation. The horizontal and vertical axes represent different values of λ and cvl, respectively. The crossing of the red dotted line represents λ of 10.289 when cvl takes the maximum (−475.733). (B) Coefficient distribution diagram of the optimal combination of prognostic genes based on the Cox proportional hazards model. cvl, cross-validation likelihood; ANKS1B, ankyrin repeat and sterile α motif domain-containing protein 1B; CAMK1, calcium/calmodulin dependent protein kinase I; CES, carboxylesterase 1; CTLA4, cytotoxic T-lymphocyte associated protein 4; CXCL2, C-X-C motif chemokine ligand 2; DNAJC12, DnaJ heat shock protein family member C12; EFNA5, ephrin A5; FEZ1, fasciculation and elongation protein ζ1; HOPX, HOP homeobox; HPCAL4, hippocalcin like 4; IL17RB, interleukin 17 receptor B; MUC16, mucin 16, cell surface associated.