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. 2019 Aug 29;20(4):3679–3690. doi: 10.3892/mmr.2019.10627

Table III.

GO and KEGG pathway enrichment results for DEGs.

A, Biological process

Term Count P-value
GO:0006974~response to DNA damage stimulus 32 2.47×10−04
GO:0006281~DNA repair 26 4.14×10−04
GO:0045184~establishment of protein localization 50 0.002456
GO:0006259~DNA metabolic process 36 0.002753
GO:0015031~protein transport 49 0.003342
GO:0008104~protein localization 55 0.003533
GO:0022402~cell cycle process 38 0.00521
GO:0033554~cellular response to stress 38 0.005394
GO:0007049~cell cycle 48 0.007516
GO:0051301~cell division 22 0.013451
GO:0022403~cell cycle phase 28 0.016532
GO:0000278~mitotic cell cycle 25 0.024163
GO:0032989~cellular component morphogenesis 26 0.029787
GO:0042127~regulation of cell proliferation 45 0.032887
GO:0000279~M phase 22 0.038695
GO:0042981~regulation of apoptosis 45 0.045193

B, Cellular component
Term Count P-value

GO:0031974~membrane-enclosed lumen 101 5.31×10−04
GO:0043233~organelle lumen 99 6.35×10−04
GO:0070013~intracellular organelle lumen 97 6.75×10−04
GO:0031981~nuclear lumen 76 0.008073
GO:0019898~extrinsic to membrane 31 0.012421
GO:0000793~condensed chromosome 12 0.012999
GO:0009897~external side of plasma membrane 14 0.017106
GO:0005578~proteinaceous extracellular matrix 21 0.028573
GO:0043235~receptor complex 10 0.039703

C, Molecular function

Term Count P-value

GO:0019955~cytokine binding 11 0.014221
GO:0019900~kinase binding 15 0.015941
GO:0005524~ATP binding 75 0.041085
GO:0019899~enzyme binding 31 0.042744
GO:0030554~adenyl nucleotide binding 79 0.046193

D, KEGG pathway

Term Count P-value

hsa04060:Cytokine-cytokine receptor interaction 20 0.002507
hsa04115:p53 signaling pathway 7 0.008288
hsa00590:Arachidonic acid metabolism 5 0.024164
hsa00010:Glycolysis/Gluconeogenesis 5 0.028166
hsa04062:Chemokine signaling pathway 11 0.032858
hsa04660:T cell receptor signaling pathway 7 0.035535
hsa04514:Cell adhesion molecules (CAMs) 8 0.038001
hsa04110:Cell cycle 7 0.04925

GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; DEG, differentially expressed gene.