Figure 4.

Upregulation of IL-10 and TLR3, and downregulation of IL-6, TNF-α, CRP, TLR4 and TLR5 following the treatment of patients with AS using infliximab. Serum levels of (A) IL-6, (B) IL-10, (C) TNF-α and (D) CRP in patients with AS before and after treatment, as determined via ELISA. (E) mRNA levels of TLRs were detected via reverse transcription-quantitative PCR. *P<0.05, **P<0.01 vs. before treatment. AS, ankylosing spondylitis; CRP, C-reactive protein; IL, interleukin; TLR, Toll-like receptor; TNF-α, tumor necrosis factor-α.