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. 2019 Aug 21;20(4):3728–3734. doi: 10.3892/mmr.2019.10601

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Sam68 mediates HG-induced podocyte apoptosis. (A) Podocytes cultured under different conditions were stained with Annexin V-FITC/PI for flow cytometric analysis. Cells that stained positive for Annexin V-FITC and negative for PI were considered apoptotic. (B) Histogram revealing changes in the percentage of apoptotic cells. NG (5.3 mM) group; HG group (30 mM); MA, NG (5.3 mM)+MA (24.7 mM) group, as an osmolality control; HG+Sam68-siRNA, HG (30 mM)+Sam68-siRNA (50 nM) group; HG+Con-siRNA, HG (30 mM)+non target-siRNA (50 nM) group. Data are expressed as the mean ± SEM. The experiments were performed in triplicate. *P<0.01, HG or HG+Con-siRNA vs. NG; ^#P<0.01, HG+Sam68-siRNA vs. HG. Src-associated substrate during mitosis of 68 kDa; HG, high glucose; NG, normal glucose; HG, high glucose; MA, mannitol.