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. 2019 Aug 14;20(4):3583–3596. doi: 10.3892/mmr.2019.10588

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Copyright: © Sun et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — PPI network construction for the OxPt resistance group. (A) PPI network for screened lncRNA-targeted DEGs. Genes marked in red represent hub genes with a degree ≥5 (color and size are increased along with degree value). The darker the connection line, the greater the confidence score. (B) lncRNA-mRNA association network. Circles indicate mRNAs and diamonds indicate non-protein-coding RNAs. A larger node indicates a larger log₂FC value. Upregulated genes are shown in pink and downregulated genes are shown in blue. PPI, protein-protein interaction; lncRNA, long noncoding RNA; OxPt, oxaliplatin; DEG, differentially expressed genes; FC, fold-change.