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. 2019 Aug 9;20(4):3003–3010. doi: 10.3892/mmr.2019.10577

Figure 5.

Figure 5.

C-Myc promotes HMGCR expression. (A) c-Myc overexpression upregulated HMGCR mRNA expression levels. **P<0.01 vs. respective c-Myc. (B) Knockdown of c-Myc downregulated HMGCR mRNA expression levels. **P<0.01 vs. respective si con. (C) c-Myc activated the HMGCR promoter. **P<0.01 vs. respective 0 µg c-Myc. (D) Chromatin immunoprecipitation assay reveals c-Myc binding to the HMGCR promoter. Quantitative polymerase chain reaction was performed. **P<0.01 vs. IgG. (E) c-Myc knockdown rescued the effects of SREBP2 on promoting HMGCR expression. **P<0.01; ##P<0.01. con, control; HMGCR, 3-hydroxy 3-methylglutaryl coenzyme A reductase; si, small interfering RNA; SREBP2, sterol regulatory element-binding protein 2; IgG, immunoglobulin G.