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. 2019 Aug 21;20(4):3811–3819. doi: 10.3892/mmr.2019.10598

Figure 2.

Figure 2.

COX-2 overexpression increases migration and invasion in MG-63 cells. MG-63 cells were infected with control or COX-2-overexpressing lentivirus, and treated with or without the COX-2 inhibitor NS398 or the PI3K inhibitor LY294002. (A) Transwell chambers were used to detect changes in the migration ability of each group. (B) Quantification of cell migration. (C) Matrigel-coated Transwell chambers were used to detect changes in the invasion ability of each group. (D) Quantification of cell invasion. Magnification, ×200. #P<0.05, ##P<0.01 vs. plvx-DsRed; **P<0.01 vs. plvx-COX2-DsRed. COX-2, cyclooxygenase-2; plvx-DsRed, empty vector; plvx-COX2-DsRed, vector overexpressing COX-2.