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. 2019 Aug 21;20(4):3811–3819. doi: 10.3892/mmr.2019.10598

Figure 4.

Figure 4.

Expression of MMP-2, MMP-9 and VEGF is regulated by COX-2. MG-63 cells were infected with control or COX-2-overexpressing lentivirus, and treated with or without the COX-2 inhibitor NS398 or the PI3K inhibitor LY294002. The change in MMP-2, MMP-9 and VEGF levels (A) in the supernatant and (B) inside the cell was determined using ELISAs. ##P<0.01 vs. plvx-DsRed; **P<0.01 vs. plvx-COX2-DsRed. COX-2, cyclooxygenase-2; MMP, matrix metallopeptidase; VEGF, vascular endothelial growth factor; plvx-DsRed, empty vector; plvx-COX2-DsRed, vector overexpressing COX-2.