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. 2019 Aug 26;20(4):3519–3526. doi: 10.3892/mmr.2019.10616

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — miR-608 mediates cisplatin sensitivity by regulating TEAD2 in non-small cell lung cancer cells. (A) Transfection of TEAD2 overexpression plasmid increased the protein expression level of TEAD2 in A549 cells. (B) Semi-quantification of the protein expression level of TEAD2. (C) Overexpression of miR-608 increased cisplatin sensitivity in A549 cells, and overexpression of TEAD2 reversed this effect. (D) Overexpression of miR-608 increased cisplatin-induced apoptosis in A549 cells, and overexpression of TEAD2 attenuated this effect. (E) Quantification of apoptotic cells. **P<0.01, ***P<0.001. miR, microRNA; TEAD2, TEA domain transcription factor 2; PI, propidium iodide.