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. 2019 Aug 1;20(4):3103–3112. doi: 10.3892/mmr.2019.10548

Figure 1.

Figure 1.

COL12A1 mRNA expression is upregulated in GC tissues and cell lines. (A) The expression of COL12A1 in three datasets. GSE7901 contains 45 GC and 5 normal gastric tissues. GSE63089 and GSE79973 contain 45 and 10 paired GC and normal gastric tissues, respectively. (B) The data-mining analysis showed that COL12A1 was upregulated in the TCGA gastric cancer portal (34 normal gastric samples and 415 primary tumor samples). (C) The data-mining analysis showed the expression status of COL12A1 in the TCGA gastric cancer portal based on different TNM stages (normal gastric samples and tumor samples classified to stage1, stage2, stage3 and stage4). (D) Basic protein expression levels of COL12A1 in normal organs. (E) Basic mRNA expression levels of COL12A1 in normal organs. (F) COL12A1 expression levels in 64 pairs of fresh normal gastric and GC tissues (COL12A1/GAPDH). (G) COL12A1 expression levels in 64 patients with GC (normalized to normal samples). (H) COL12A1 mRNA expression was examined by reverse transcription-quantitative PCR and normalized to GAPDH expression in four GC cell lines. ***P<0.001. COL12A1, collagen type XII α1 chain; TCGA, The Cancer Genome Atlas; GC, gastric cancer.