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. 2019 Sep 2;20(4):3849–3857. doi: 10.3892/mmr.2019.10634

Figure 2.

Figure 2.

The effect of RMRP knockdown on the Ang-II-induced cardiac fibroblasts activation. (A) The effect of Ang-II and TGF-β1 on the RMRP expression of cardiac fibroblasts. The effect of RMRP siRNA on the (B) RMRP expression, (C) cell viability, (D) proliferation, (E) mRNA and (F) protein expression of α-SMA and (G) Collagen of Ang-II-treated cardiac fibroblasts. Magnification, ×400 for the EdU images of D. Data are mean ± standard error of the mean. n=3 independent experiments. **P<0.01 vs. Con; #P<0.05 and ##P<0.01 vs. Ang-II. NC, RMRP siRNA negative control; si, small interfering; Con, control; TGD, transforming growth factor; α-SMA, α-smooth muscle actin; RMRP, RNA component of mitochondrial RNA processing endoribonuclease; Ang II, angiotensin II.