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. 2019 Aug 7;20(4):3035–3042. doi: 10.3892/mmr.2019.10567

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Copyright: © Gao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Expression pattern of OPG. (A and B) Volcano plot and heatmap of differential protein expression comparing extracellular protein levels between tooth germs and samples of isolated dental mesenchyme. OPG is indicated in the figures. In the volcano plot, the log₂ fold change was calculated by comparing tooth germs vs. the dental mesenchyme. Microarray analysis for tooth germs and the dental mesenchyme was performed in triplicate. (C) Spatial-temporal pattern of OPG expression during tooth development. At first, OPG expression was confined to the dental epithelium (a1 and a2). Then, OPG expression in the dental mesenchyme gradually increased as development proceeded (b-f). (C) The red arrows indicate parts of the tissue that were positive for immunohistochemical staining. Scale bar, 50 µm. OPG, osteoprotegerin; TG, tooth germ; ME, dental mesenchyme; am, ameloblasts; d, dentin; de, dental epithelium; dm, dental mesenchyme; md, mandible; od, odontoblast.