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. 2019 Aug 7;20(4):3035–3042. doi: 10.3892/mmr.2019.10567

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Copyright: © Gao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — OPG promotes the Wnt/β-catenin signaling pathway. (A) Effect of OPG on the Wnt/β-catenin signaling pathway, revealed in red arrows (schematic). (B) RT-qPCR revealing that OPG increased the expression of WNT3A (a) and β-catenin (c) and decreased DKK-1 expression (b) in E14.5 tooth germs. (C) Immunofluorescence assay for intranuclear translocation of β-catenin. (a) Tooth germ cultured without OPG supplementation was used as control, OPG at 100 (b) and 200 ng/ml (c) promoted the intranuclear translocation of β-catenin. Scale bar, 50 µm (a1-a3, b1-b3 and c1-c3); a4, b4 and c4 are regional enlargements of a3, b3 and c3. Data are expressed as the mean ± SD. **P<0.01, ***P<0.001. OPG, osteoprotegerin; Wnt, wingless/integrated.