Table III.

Top 10 downregulated genes in osteosarcoma.

Gene symbol	Log2FC	AveExp	t-score	P-value	Padj
KRTAP1-5	−5.36	5.76	−17.48	<0.001	<0.001
DKK1	−4.68	7.14	−7.45	<0.001	<0.001
STC2	−4.25	6.78	−16.57	<0.001	<0.001
TFPI2	−4.23	5.06	−11.62	<0.001	<0.001
PTX3	−4.19	8.95	−7.46	<0.001	<0.001
RGS4	−4.08	6.30	−12.49	<0.001	<0.001
NPR3	−4.07	5.77	−16.82	<0.001	<0.001
DSP	−4.00	6.85	−8.51	<0.001	<0.001
LTBP2	−3.99	7.91	−12.64	<0.001	<0.001
VGLL3	−3.91	5.93	−8.69	<0.001	<0.001

AveExp, average expression across all samples; Log₂FC, Log₂(fold change); P^adj, adjusted P-value; t-score, statistic value for t-test.