Table 1.

Ceftobiprole and ceftaroline breakpoints and ECOFF values of bacterial species and groups, according to EUCAST-2019.

Microorganism	Ceftobiprole			Ceftaroline
	Clinical breakpoints (mg/L)		ECOFF (mg/L)	Clinical breakpoints (mg/l)		ECOFF (mg/L)
	Susceptible (≤)	Resistant (>)		Susceptible (≤)	Resistant (>)
S. aureus(including MRSA)	2	2	1	1*	1** 2***	0.5
S. pneumoniae(including PNSa)	0.5	0.5	0.03	0.25	0.25	0.03
E. faecalis	-b	-	NDc	-	-	ND
Enterobacterales	0.25	0.25	0.12-0.25	0.5	0.5	0.12-0.25
P. aeruginosa	IEd	IE	8	-	-	ND
H. influenzae	IE	IE	0.25	0.03	0.03	0.03
M. catarrhalis	IE	IE	ND	IE	IE	ND
Non-species relatede	4f	4	-	0.5	0.5	-

^*Including pneumonia

^**Pneumonia isolates

^***Other isolates than pneumonia

^aPenicillin-non-susceptible

^b-: no breakpoint

^cND: not determined;

^dIE: insufficient evidence

^ePK-PD breakpoints

^fBased on PK-PD target for Gram-negative organisms.