Table 3.
circRNAs | Biological context | Targets | Experimental model |
---|---|---|---|
Inducing EndMT | |||
CircHECW2 | Pathology—Neuroinflammatory disorders | miR-30d that targets ATG5 | In vitro—Human brain microvascular endothelial cells130 |
In vivo—Mouse brain | |||
CircRNA-MYLK | Pathology—Bladder carcinoma | miR-29a that targets VEGFA | In vitro—Human bladder carcinoma cells131 |
In vivo—Mouse xenografts | |||
CircHECTD1 | Pathology—Pulmonary disease | HECTD1 | In vitro—Mouse microvascular lung cells135 |
In vivo—Lung silicosis in mouse model and human samples | |||
Inhibiting EndMT | |||
CircDLGAP4 | Pathology—Ischaemic stroke | miR-143 that targets HECTD1 | In vivo—Mouse brain136 |
List of circRNAs regulating EndMT categorized into their inducing or inhibiting role on EndMT.
ATG5, autophagy related 5; HECTD, HECT domain E3 ubiquitin protein ligase; VEGF, vascular endothelial growth factor.