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. 2019 Sep 3;115(12):1716–1731. doi: 10.1093/cvr/cvz211

Table 3.

Known circRNAs involved in EndMT

circRNAs Biological context Targets Experimental model
Inducing EndMT
 CircHECW2 Pathology—Neuroinflammatory disorders miR-30d that targets ATG5 In vitro—Human brain microvascular endothelial cells130
In vivo—Mouse brain
 CircRNA-MYLK Pathology—Bladder carcinoma miR-29a that targets VEGFA In vitro—Human bladder carcinoma cells131
In vivo—Mouse xenografts
 CircHECTD1 Pathology—Pulmonary disease HECTD1 In vitro—Mouse microvascular lung cells135
In vivo—Lung silicosis in mouse model and human samples
Inhibiting EndMT
 CircDLGAP4 Pathology—Ischaemic stroke miR-143 that targets HECTD1 In vivo—Mouse brain136

List of circRNAs regulating EndMT categorized into their inducing or inhibiting role on EndMT.

ATG5, autophagy related 5; HECTD, HECT domain E3 ubiquitin protein ligase; VEGF, vascular endothelial growth factor.