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. 2019 Jan 3;115(12):1778–1790. doi: 10.1093/cvr/cvy306

Figure 4.

Figure 4

Enhanced LV haemodynamics in young AC8TG evaluate towards normalized LV systolic pressure in aged AC8TG but blunted β-AR responsibility in both ages NTG and AC8TG mice. Haemodynamic recording was performed in 2-month-old (n = 9) and 12-month-old (n = 12) NTG and 2-month-old (n = 9) and 12-month-old (n = 15) AC8TG mice. The following parameters were measured in NTG (○) and AC8TG (●) mice at baseline and after ISO stimulation: HR (b.p.m.) (A); LVSP–LV systolic pressure (B); ΔP–LV pressure variation; dp/dtmax (C) and dp/dtmin (D). (E) Typical traces of haemodynamic recordings obtained in NTG and AC8TG mice. ISO was injected IP at the indicated concentrations during haemodynamic recording. *P < 0.05, **P < 0.01; ***P < 0.001; ***P < 0.001 vs. NTG at the same condition (Student’s unpaired t-tests).