miR-98-5p expression during osteogenic differentiation. (A) Extracellular ALP activity of the indicated cell lines. mRNA levels of (B) hBMMSC, (C) mBMMSC and (D) MC3T3-E1 osteoblast makers including Runx2, ALP and Osterix. (E) miR-98-5p expression in hBMMSC, mBMMSC and MC3T3-E1 cells during osteogenic differentiation. Data are presented as the mean ± standard deviation. **P<0.01 vs. day 0. miR, microRNA; ALP, alkaline phosphatase; hBMMSC, human bone marrow-derived mesenchymal stem cells; mBMMSC, mouse bone marrow-derived mesenchymal stem cells; Runx2, runt related transcription factor 2; Osterix, transcription factor sp7.