. 2019 Aug 14;18(4):2993–3001. doi: 10.3892/etm.2019.7896

Table III.

Univariate and multivariate analysis of prognostic variables for esophageal squamous cell carcinoma.

	Overall survival			Disease-free survival

	Univariate analysis	Multivariate analysis	Univariate analysis	Multivariate analysis
Variable	P-value	HR (95% CI)	P-value	P-value	HR (95% CI)	P-value
Sex		1.528			0.699
Male vs. female	0.598	(0.670–3.484)	0.313	0.999	(0.303–1.613)	0.402
Age		0.559			0.941
<60 vs. ≥60	0.030^a	(0.318–0.981)	0.043^a	0.585	(0.533–1.662)	0.835
Smoking		0.931			0.639
Yes vs. no	0.921	(0.469–1.847)	0.838	0.212	(0.335–1.218)	0.174
Drinking		1.910			0.951
Yes vs. no	0.282	(0.957–3.812)	0.067	0.762	(0.488–1.851)	0.882
T stage		0.872			0.785
T1-2 vs. T3 −4	0.445	(0.466–1.631)	0.668	0.452	(0.422–1.458)	0.443
N stage		1.530			1.035
N0 vs. N1-3	<0.001^a	(0.533–4.395)	0.430	0.001^a	(0.365–2,937)	0.948
Differentiation		0.783			0.885
Well vs. moderate vs. poor	0.658	(0.526–1.165)	0.227	0.915	(0.595–1.316)	0.545
pTNM		1.805			3.108
I–II vs. III	<0.001^a	(0.608–5.357)	0.287	<0.001^a	(1.038–9.310)	0.043^a
YAP expression		2.727			2.161
Low vs. over	0.001^a	(1.556–4.780)	<0.001^a	0.005^a	(1.223–3.818)	0.008^a
CRT		0.974			0.907
None vs. RT vs.	0.785	(0.768–1.237)	0.831	0.620	(0.708–1.163)	0.443
CT vs. RT+CT

P<0.05. HR, hazard ratio; CI, confidence interval; RT, radiotherapy; CT, chemotherapy; CRT, Radiochemotherapy; T stage, invasion depth; N stage, lymph node metastasis; pTNM, pathological TNM.