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. 2019 Jul 31;6(18):1901441. doi: 10.1002/advs.201901441

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© 2019 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Microbial and metabolite markers for MG. a) the association between MG severity and microbial OTUs. 21 OTUs were significantly linked with MG severity (QMG score and HRC). Majority of these OTUs mainly belonged to Lachnospiraceae (6 OTUs), Erysipelotrichaceae (4 OTUs), and Bacteroidaceae (2 OTUs) at family level. Red dots indicate the upregulated microbial OTUs, while blue dots indicate the downregulated OTUs in MG related to HCs. The thickness of the line represents the size of the p‐value (p < 0.05). b) diagnostic markers for MG: Combination of 4 microbial marker (Clostridiaceae 1, Lachnospiraceae, Erysipelotrichaceae, and Bacteroidaceae) and 6 metabolites (leucine, cytosine, oxalicacid, N‐Acetyltryptophan, d‐Glyceric acid, and xanthine) can distinguish the MG from HCs with an area under the curve (AUC) of 1 (accuracy of 100%), which was significantly higher than that of separate microbial or metabolic markers.