Table 2.
Effect of tDCS on trigeminal nociceptive processing
| MNI X Y Z |
Anatomical area | kE | T | pFWE cluster |
pFWE peak |
|
|---|---|---|---|---|---|---|
| −22 8–16 | L | Amygdalaa | 107 | 4.48 | .005 | .001 |
| −12 2 4 | L | Basal gangliaa | 208 | 4.24 | .033 | .006 |
| 26 0–20 | R | Amygdalaa | 125 | 4.18 | .002 | .001 |
| 56–30 -8 | R | Mid. temporal gyrus | 74 | 4.17 | NA | NA |
| −10 -28 70 | L | M1 and premotor cortexa | 162 | 4.11 | .010 | .012 |
| −14 -10 18 | L | Thalamusa | 39 | 3.99 | .015 | .008 |
| 56–18 6 | R | Superior temporal gyrus | 86 | 3.97 | NA | NA |
| 14 4 6 | R | Basal gangliaa | 94 | 3.93 | .027 | .029 |
| −50 -32 12 | L | Superior temporal gyrus | 49 | 3.85 | NA | NA |
| 66–8 18 | R | Postcentral gyrusa | 24 | 3.81 | .042 | .025 |
| −40 -2 -18 | L | Posterior Insular cortex | 27 | 3.77 | NS | NS |
| −6 -4 44 | L | Cingulate cortexa | 47 | 3.77 | .03 | .027 |
| 10–24 74 | R | Suppl. motor/premotor cortex | 25 | 3.73 | NS | NS |
| 4 14 0 | R | Basal ganglia / Caudate ncl.a | 59 | 3.68 | .027 | .032 |
| 38 2 54 | R | DLPFCa | 44 | 3.67 | .044 | .047 |
| 44 42 4 | R | DLPFC | 42 | 3.58 | NS | NS |
Areas with significant DC-stimulation induced alterations (postcathodal vs. postanodal). Illustration in Fig. 2. Exploratory significance level punc < .0005. Additional region of interest analysis (ROI) with applied Family-Wise-Error correction for the neuropain-matrix as indicated in the materials and method section (apFWE < 0.05)
R = right, L = left, BL = bilateral, Ke = cluster extend, MNI = Montreal Neurological Institute: NA = not applicable, NS = not significant. M1 = primary motorcortex, DLPFC = dorsolateral prefrontal cortex